Explanation senora concocted (6)
I believe the answer is:
reason
'explanation' is the definition.
(reason is a kind of explanation)
'senora concocted' is the wordplay.
'concocted' is an anagram indicator.
'senora' is an anagram of 'REASON'.
(Other definitions for reason that I've seen before include "Sanity of senora" , "Justification; sanity" , "Employ logic" , "Cause; mind's power" , "Justification (for action)" .)