Extreme fatigue following air travel (3,3)
![Ross](/clue/static/ross-mug.min.png)
I believe the answer is:
jet lag
(Other definitions for jet lag that I've seen before include "Tiredness after long plane trip" , "Feeling of tiredness after long air flight" , "traveller's complaint" , "Post-flight exhaustion" , "Delayed tiredness after long plane journey" .)