Extreme foolishness, but with any luck almost all will reform (6)
I believe the answer is:
lunacy
'extreme foolishness' is the definition.
'lunacy' can be an answer for 'foolishness' (thesaurus). I'm not certain of the 'extreme' bit.
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for lunacy that I've seen before include "Madness, insanity" , "Tomfoolery" , "Extreme folly, insanity" , "Craziness, madness" , "State of madness" .)