Extremely anxious fool's suspect ethics (10)

I believe the answer is:

twitchiest

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'extremely anxious' is the definition.
I can't judge whether this defines the answer.

'fool's suspect ethics' is the wordplay.
'fool' becomes 'twit' (both can mean a stupid person).
'suspect' indicates anagramming the letters (a suspicious or unusual spelling).
'ethics' is an anagram of 'chiest'.
'twit'+'chiest'='TWITCHIEST'

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(Another definition for twitchiest that I've seen is " most ill at ease".)

I've seen this clue in The Independent.

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