Extremely insensitive (4)
I believe the answer is:
dead
This clue is a double definition.
'extremely' is the first definition.
(as in a phrase like 'dead easy')
'insensitive' is the second definition.
(I've seen this before)
(Other definitions for dead that I've seen before include "No longer living" , "No longer alive" , "Defunct" , "Devoid of life" , "Passed on" .)