Extremely large spots itch horribly, most in patches (11)
I believe the answer is:
splotchiest
'extremely large spots itch horribly most in patches' is the definition.
I can't judge whether this definition defines the answer.
'extremely large spots itch horribly' is the wordplay.
'extremely' means to remove the middle letters.
'horribly' indicates anagramming the letters.
'large' with its middle removed is 'le'.
'le'+'spots'+'itch'='lespotsitch'
'lespotsitch' with letters rearranged gives 'SPLOTCHIEST'.
Can you help me to learn more?
I've seen this clue in The Times.
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