Extremely nervous? (4)
I believe the answer is:
edgy
This clue is a double definition.
'extremely' is the first definition.
(I've seen this before)
'nervous?' is the second definition.
('edgy' can be a synonym of 'nervous')
(Other definitions for edgy that I've seen before include "ready to flap?" , "Jittery" , "Keyed up" , "Red shade" , "Nervous and tense, irritable" .)