Fail to embrace South American neglect (6)
I believe the answer is:
disuse
'neglect' is the definition.
(I've seen this before)
'fail to embrace south american' is the wordplay.
'fail' becomes 'die' ('die' can be a synonym of 'fail').
'to embrace' means one lot of letters goes inside another.
'south american' becomes 'sus' (I've seen this in other clues).
'die' going around 'sus' is 'DISUSE'.
(Other definitions for disuse that I've seen before include "Neglect; abandonment" , "Neglect; desuetude" , "Fall into this state to be unemplyed? (6)." , "Issued (anag)" , "State of not being employed" .)