Fame affects mad sort (7)
I believe the answer is:
stardom
'fame' is the definition.
(I've seen this before)
'affects mad sort' is the wordplay.
'affects' indicates an anagram (I've seen 'affected' mean this).
'mad'+'sort'='madsort'
'madsort' with letters rearranged gives 'STARDOM'.
(Other definitions for stardom that I've seen before include "Great fame" , "wide renown" , "Status of a top actor" , "Stage or screen fame" , "Celebrity status" .)