Fame, in certain ways, can be worn out! (6)
I believe the answer is:
renown
'fame' is the definition.
(I know that fame can be written as renown)
'certain ways can be worn out' is the wordplay.
'certain ways' becomes 'en' (I can't explain this - if you can you should believe this answer much more).
'can be' is an anagram indicator.
'out' indicates putting letters inside.
'worn' with letters rearranged gives 'rown'.
'en' inserted into 'rown' is 'RENOWN'.
'in' acts as a link.
Can you help me to learn more?
(Other definitions for renown that I've seen before include "High reputation, fame" , "Fame, respect" , "Fame and distinction" , "Plane's maximum width" , "Fame and public acclamation" .)