Familiar from birth with line from Hamlet (2,3,6,4)
I believe the answer is:
to the manner born
I believe this is a double definition.
'familiar from birth' is the first definition.
(phrase meaning familiar with or used to from birth)
'line from hamlet' is the second definition.
(quotation from Shakespeare's Hamlet)
'with' is the link.
(Other definitions for to the manner born that I've seen before include "accustomed to certain standards" , "with a natural aptitude?" , "with innate skill" , "Naturally fitted for role" , "like a natural" .)