Familiar with a motorway journey (5)
I believe the answer is:
amigo
'familiar' is the definition.
(thesaurus)
'with a motorway journey' is the wordplay.
'with' says to put letters next to each other.
'motorway' becomes 'MI' (resembles M1, English motorway).
'journey' becomes 'go' (I've seen this in other clues).
'a' next to 'mi' is 'ami'.
'ami'+'go'='AMIGO'
(Other definitions for amigo that I've seen before include "friend from Barcelona" , "in a foreign land, my friend?" , "Friend, comrade" , "Mexican's mate" , "A Mexican pal" .)