Famous Roman port city's nickname (6)
I believe the answer is:
pompey
This clue is a double definition.
'famous roman' is the first definition.
(Pompey was a Roman statesman)
'port city's nickname' is the second definition.
(nickname of Portsmouth)
(Other definitions for pompey that I've seen before include "Nickname of an English port shared with a Roman general" , "name for Portsmouth" .)