Fan may see trouble following a lie having lost heart (10)
I believe the answer is:
aficionado
'fan' is the definition.
(I've seen this before)
'may see trouble following a lie having lost heart' is the wordplay.
'may see' becomes 'a' (I can't justify this - if you can you should believe this answer much more).
'trouble' becomes 'ado' (both can mean bother or commotion).
'following' is a charade indicator (letters next to each other).
'a lie' becomes 'fiction' (I've seen this before).
'having lost heart' suggests removing the centre.
'fiction' with its middle removed is 'ficion'.
'ado' put after 'ficion' is 'ficionado'.
'a'+'ficionado'='AFICIONADO'
Can you help me to learn more?
(Other definitions for aficionado that I've seen before include "freak" , "Informed enthusiast" , "lover" , "Admirer" , "Expert person" .)