Fat female leading team of scientists? (4)
I believe the answer is:
flab
'fat' is the definition.
(I know that flab is a type of fat)
'female leading team of scientists?' is the wordplay.
'leading' indicates taking the first letters.
'team of scientists?' becomes 'lab' (laboratory).
The initial letter of 'female' is 'f'.
'f'+'lab'='FLAB'
(Other definitions for flab that I've seen before include "Soft loose flesh" , "Excess body fat" , "Unwanted body fat" , "spare tyre?" , "Ugly, surplus flesh" .)