Father, at home, is irksome (4)
I believe the answer is:
pain
'home is irksome' is the definition.
I can't tell whether this defines the answer.
'father at' is the wordplay.
'father' becomes 'pa' (pa can mean dad or father).
'at' becomes 'in'.
'pa'+'in'='PAIN'
Can you help me to learn more?
(Other definitions for pain that I've seen before include "Physical hurt" , "Physical discomfort" , "Sensation of acute discomfort" , "Hurt feeling" , "Unpleasant sensation" .)