Father's upset, hurt by Native American (6)
I believe the answer is:
apache
'native american' is the definition.
(group of Native American tribes)
'father's upset hurt by' is the wordplay.
'father' becomes 'pa' (pa can mean dad or father).
'upset' says the letters should be written in reverse.
'hurt' becomes 'ache' (synonyms).
'by' says to put letters next to each other.
'pa' in reverse letter order is 'ap'.
'ap'+'ache'='APACHE'
(Other definitions for apache that I've seen before include "American speech" , "Indians" , "American Indian - French gangster" , "on the streets of Paris" , "ruffian in capital of France" .)