Favourite ingredient of pipe tobacco (3)
I believe the answer is:
pet
'favourite' is the definition.
(synonyms)
'ingredient of pipe tobacco' is the wordplay.
'ingredient of' indicates the answer is hidden within the clue.
'PET' is hidden within 'pipe tobacco'.
(Other definitions for pet that I've seen before include "Favourite pupil" , "Caress or fondle, as with favourite" , "Favourite, may be teacher's" , "Tamed domestic animal" , "Loved domestic animal" .)