Fed up with the dire chaos after trouble starts (5)
I believe the answer is:
tired
'fed up' is the definition.
(thesaurus)
'dire chaos after trouble starts' is the wordplay.
'chaos' is an anagram indicator.
'after' means one lot of letters go next to another.
'starts' indicates taking the first letters.
The initial letter of 'trouble' is 't'.
'dire' anagrammed gives 'ired'.
'ired' put after 't' is 'TIRED'.
'with the' is the link.
(Other definitions for tired that I've seen before include "Beat" , "getting bored" , "In need of rest" , "Physically or mental weary" , "Worn out" .)