Feel depressed downstairs (5)
I believe the answer is:
below
'downstairs' is the definition.
(synonyms)
'feel depressed' is the wordplay.
'feel' becomes 'be'.
'depressed' becomes 'low' (similar in meaning).
'be'+'low'='BELOW'
(Other definitions for below that I've seen before include "Feel miserable" , "in one's cabin" , "Underneath" , "Lower than" , "as mentioned later" .)