Feel the loss of our island state (8)
I believe the answer is:
missouri
'state' is the definition.
(I know that Missouri is a American state)
'feel the loss of our island' is the wordplay.
'feel the loss of' becomes 'miss' (I've seen this in another clue).
'island' becomes 'i' (geographical abbreviation).
'miss'+'our'+'i'='MISSOURI'
(Other definitions for missouri that I've seen before include "US state, capital Jefferson City" , "Longest river in the US, joining the Mississippi at St Louis" , "Flower" , "US river - state" , "American state, capital Jefferson City" .)