Feeling exhausted and isolated (3,2,5)
I believe the answer is:
out of touch
'isolated' is the definition.
I know nothing about this answer so I cannot judge whether it can be defined by this definition.
'feeling exhausted' is the wordplay.
I cannot quite understand how this works, but
'feeling' could be 'touch' (touch is a kind of feeling) and 'touch' is present in the answer.
'exhausted' could be 'out' (I've seen this in other clues) and 'out' is found within the answer.
The remaining letters 'of' is a valid word which might be clued in a way I don't see.
This explanation may well be incorrect...
'and' is the link.
(Other definitions for out of touch that I've seen before include "old-fashioned" , "Not in communication with" , "in play, presumably" , "Not au fait with recent developments" , "Not up-to-date: not in form" .)