Fellows with the best cards constitute threats (7)
I believe the answer is:
menaces
'threats' is the definition.
('menace' can be a synonym of 'threat')
'fellows with the best cards' is the wordplay.
'fellows' becomes 'men' (fellow can mean a man).
'with' is a charade indicator (letters next to each other).
'the best cards' becomes 'aces' (ace is a kind of card. I am not sure about the 'best' bit.).
'men'+'aces'='MENACES'
'constitute' acts as a link.
I am not very happy about this link. It may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for menaces that I've seen before include "Threats" , "Threatens" .)