Female explosion in affair (7)
I believe the answer is:
shebang
'affair' is the definition.
('shebang' can informally refer to a matter or situ)
'female explosion' is the wordplay.
'female' becomes 'she' ('she' refers to a woman).
'explosion' becomes 'bang' (I've seen this before).
'she'+'bang'='SHEBANG'
'in' is the link.
(Other definitions for shebang that I've seen before include "Matter" , "affair in America" , "(Whole) kit and caboodle" , "Lot" , "The entire system" .)