Female invariably creating state of excitement (5)
I believe the answer is:
fever
'state of excitement' is the definition.
(I've seen this before)
'female invariably' is the wordplay.
'female' becomes 'f' (common abbreviation).
'invariably' becomes 'ever' (I've seen this in another clue).
'f'+'ever'='FEVER'
'creating' acts as a link.
(Other definitions for fever that I've seen before include "Intense nervous excitement or anticipation?" , "High-temperature illness" , "Pyrexia" , "Nervous excitement, high temperature" , "eg Malaria" .)