Female priest who takes charge of things? (8)
I believe the answer is:
director
'who takes charge of things?' is the definition.
'female priest' is the wordplay.
'female' becomes 'di' (short for Diana).
'priest' becomes 'rector' (I've seen this before).
'di'+'rector'='DIRECTOR'
(Other definitions for director that I've seen before include "One who controls resources and expenditures" , "Creditor (anag.)" , "Company board member" , "leader" , "One on board" .)