Female sick, not going to make it (7)
I believe the answer is:
failing
'not going to make it' is the definition.
I can't tell whether this definition defines the answer.
'female sick' is the wordplay.
'female' becomes 'f' (common abbreviation).
'sick' becomes 'ailing' (similar in meaning).
'f'+'ailing'='FAILING'
Can you help me to learn more?
(Other definitions for failing that I've seen before include "Flunking" , "Defect" , "becoming frail" , "conking out" , "Character weakness" .)