Female ultimately worried about male issue (7)
I believe the answer is:
emanate
'issue' is the definition.
(I've seen this before)
'female ultimately worried about male' is the wordplay.
'ultimately' says to take the final letters.
'worried' becomes 'ate' (something worrying may eat someone up).
'about' is a charade indicator (letters next to each other).
'male' becomes 'man' (man is a kind of male).
The final letter of 'female' is 'e'.
'ate' put after 'man' is 'manate'.
'e'+'manate'='EMANATE'
(Other definitions for emanate that I've seen before include "Issue or originate from manatee" , "Rise" , "spring" , "Give out, emit" , "Flow or proceed from" .)