Female wearing round cap is grief-stricken (6)
I believe the answer is:
bereft
'grief-stricken' is the definition.
('bereft' can be a synonym of 'grief-stricken')
'female wearing round cap' is the wordplay.
'female' becomes 'f' (abbreviation).
'wearing' indicates putting letters inside.
'round cap' becomes 'beret' (I've seen this before).
'f' placed within 'beret' is 'BEREFT'.
'is' acts as a link.
(Other definitions for bereft that I've seen before include "Deprived, of reason or loved one" , "Pained by the loss of someone" , "Cut off - deprived" , "Sorrowful through loss" , "Grief-stricken" .)