Female with light ran away (4)
I believe the answer is:
fled
'ran away' is the definition.
(I've seen this before)
'female with light' is the wordplay.
'female' becomes 'f' (abbreviation).
'with' means one lot of letters go next to another.
'light' becomes 'led' (abbreviation for light emitting diode).
'f'+'led'='FLED'
(Other definitions for fled that I've seen before include "Having run or hurried away" , "Female showed the way and escaped" , "dashed off elsewhere" , "Did a runner" , "Ran off in a hurry" .)