Female with place in the Middle East (5)
I believe the answer is:
woman
'female' is the definition.
(woman is a kind of female)
'with place in the middle east' is the wordplay.
'with' becomes 'w' (abbreviation).
'place in the middle east' becomes 'oman'.
'w'+'oman'='WOMAN'
(Other definitions for woman that I've seen before include "Adult female" , "See 16" , "Mature female" , "With 1a [OLD], one's rather timid" , "person not going on stag-night" .)