Female with sign of neglect deemed ''thwarted'' (10)
I believe the answer is:
frustrated
''thwarted'' is the definition.
(synonyms)
'female with sign of neglect deemed' is the wordplay.
'female' becomes 'f' (abbreviation).
'with' says to put letters next to each other.
'sign of neglect' becomes 'rust' (I've seen this in another clue).
'deemed' becomes 'rated' (both can mean judged or considered).
'f'+'rust'+'rated'='FRUSTRATED'
(Other definitions for frustrated that I've seen before include "Having a sense of discouragement and dissatisfaction" , "Disheartened" , "Thwarted" , "Foiled" , "Prevented from progressing" .)