Female wrath — it is destructive (4)
I believe the answer is:
fire
'it is destructive' is the definition.
The definition suggests a singular noun which matches the answer.
'female wrath' is the wordplay.
'female' becomes 'f' (abbreviation).
'wrath' becomes 'ire' (both can mean anger).
'f'+'ire'='FIRE'
Can you help me to learn more?
(Other definitions for fire that I've seen before include "Trigger" , "Sack; discharge (a gun)" , "Set light to; shoot" , "Inspire" , "See 5" .)