Fictional criminal mastermind (with a moustache?) (2,6)
I believe the answer is:
fu manchu
(Other definitions for fu manchu that I've seen before include "terrible Chinese doctor" , "Fictional Chinese arch-villain (Sax Rohmer)" , "Sax Rohmer's evil genius of a doctor" , "Dr -- --, fictional Asian villain" , "Sax Rohmer's oriental villain" .)