Fight with a Republican (3)
I believe the answer is:
war
'fight' is the definition.
(warring is a kind of fighting)
'with a republican' is the wordplay.
'with' becomes 'w' (abbreviation).
'republican' becomes 'r' (abbreviation).
'w'+'a'+'r'='WAR'
(Other definitions for war that I've seen before include "Open hostility" , "Fight" , "Major conflict" , "State of armed struggle" , "Period of hostilities" .)