Film-maker's car loses wheel going up street in Paris (6)
I believe the answer is:
auteur
'film-maker's' is the definition.
(type of film director)
'car loses wheel going up street in paris' is the wordplay.
'car' becomes 't'.
'loses' becomes 'ua' (I can't explain this - if you can you should give a lot more credence to this answer).
'wheel' shows that the letters should be reversed in order (I've seen 'wheeled' mean this (letters are wheeled back)).
'going up' shows that the letters should be reversed in order.
'street in paris' becomes 'rue' ('street' in French).
't'+'ua'='tua'
'tua' back-to-front is 'aut'.
'rue' in reverse letter order is 'eur'.
'aut'+'eur'='AUTEUR'
(Other definitions for auteur that I've seen before include "director who's unique" , "Film director whose work has a distinctively personal quality" .)