First appearance (5)

I think it could be either:

debut

onset

'first appearance' is the definition.
(synonyms)

This is all the clue.

(Other definitions for debut that I've seen before include "First appearance in society" , "Initial appearance" , "First attempt" , "Start -- launch" , "where one began" .)

I've seen this clue in the Universal, The Sun, the Penny Press, The Mirror, The Independent, The Times, the Evening Standard, The Telegraph, the USA Today, the Sydney Morning Herald and The Guardian.

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