First couple of children in A&E hurt (4)
I believe the answer is:
ache
'hurt' is the definition.
(synonyms)
'first couple of children in ae' is the wordplay.
'first couple' becomes 'c' (hst letter of 'couple').
'of children' becomes 'h' (I am not sure about this - if you are sure you should believe this answer much more).
'in' means one lot of letters goes inside another.
'c'+'h'='ch'
'ch' placed within 'ae' is 'ACHE'.
Can you help me to learn more?
(Other definitions for ache that I've seen before include "Dull steady pain" , "Continuous hurt" , "Shakespearean character" , "painful" , "Nagging pain" .)