First make for Berkshire town (10)
I believe the answer is:
maidenhead
'berkshire town' is the definition.
(town in Berkshire)
'first make' is the wordplay.
'first' becomes 'maiden' (as in a maiden voyage).
'make' becomes 'head' (I am not sure about this - if you are sure you should believe this answer much more).
'maiden'+'head'='MAIDENHEAD'
'for' is the link.
Can you help me to learn more?
(Other definitions for maidenhead that I've seen before include "town on the Thames" , "Place" .)