First male, a female (4)
I believe the answer is:
adam
'first male' is the definition.
'a female' is the wordplay.
'female' becomes 'dam' (dam is a kind of female**).
'a'+'dam'='ADAM'
(Other definitions for adam that I've seen before include "Man on the ceiling of the Sistine Chapel" , "Male" , "who was tempted by mate?" , "father figure" , "Eden inhabitant" .)