First musical debut disordered, missing note, and silenced (5)
I believe the answer is:
muted
'silenced' is the definition.
(muting is a kind of silencing)
'first musical debut disordered' is the wordplay.
'first' is a charade indicator (letters next to each other).
'musical' becomes 'mute' (I can't explain this - if you can you should give a lot more credence to this answer).
'debut' indicates taking the first letters.
The first letter of 'disordered' is 'd'.
'mute'+'d' is 'MUTED'.
'missing note and' is the link.
This may not be correct. Some or all of it may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for muted that I've seen before include "(Of colour) subdued" , "fitted with silencer" , "Muffled, subdued" , "with reduced volume" , "Hushed, dulled or deadened" .)