Fixed by crude manipulation (5)
I believe the answer is:
cured
'fixed' is the definition.
(I've seen this in another clue)
'crude manipulation' is the wordplay.
'manipulation' indicates anagramming the letters (I've seen this in other clues).
'crude' anagrammed gives 'CURED'.
'by' acts as a link.
(Other definitions for cured that I've seen before include "Made better or preserved" , "Made well" , "Healed - smoked" , "Healed - preserved" , "Healed or salted" .)