Fly from places in Tenerife on vacation (6)
I believe the answer is:
tsetse
'fly' is the definition.
(biting fly found in tropical Africa)
'places in tenerife on vacation' is the wordplay.
'places' becomes 'sets' ('set' can be a synonym of 'place').
'in' indicates putting letters inside.
'on vacation' means to remove the middle letters (after the inside letters have vacated the word).
'tenerife' with its centre taken out is 'te'.
'sets' put inside 'te' is 'TSETSE'.
'from' acts as a link.
(Other definitions for tsetse that I've seen before include "carrier of disease" , "bloodsucker" , "Disease-carrying fly" , "fly across Africa" , "flies" .)