Fly plague overwhelming one quicker than anything (8)
I believe the answer is:
zippiest
'quicker than anything' is the definition.
(zippy can mean quick)
'fly plague overwhelming one' is the wordplay.
'fly' becomes 'zip' (both can mean to move quickly).
'plague' becomes 'pest' (pest can mean a plague or pestilence).
'overwhelming' means one lot of letters goes inside another.
'one' becomes 'I' (Roman numeral).
'pest' enclosing 'i' is 'piest'.
'zip'+'piest'='ZIPPIEST'
(Another definition for zippiest that I've seen is " most fast!".)
I've seen this clue in The Times.
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