Follow directions with girl in tow (5)
I believe the answer is:
ensue
'follow' is the definition.
(I've seen this before)
'directions with girl in tow' is the wordplay.
'directions' becomes 'en' (I've seen this in other clues).
'with' means one lot of letters go next to another.
'girl in tow' becomes 'sue' (I can't justify this - if you can you should give a lot more credence to this answer).
'en'+'sue'='ENSUE'
Can you help me to learn more?
(Other definitions for ensue that I've seen before include "Come to pass" , "Result in a particular way" , "Occur as a result (of)" , "Come next" , "Follow afterwards" .)