Follow supreme being from the East (3)
I believe the answer is:
dog
'follow' is the definition.
(dog can mean to follow or torment)
'supreme being from the east' is the wordplay.
'supreme being' becomes 'god' (a god is a supreme being).
'from the east' says the letters should be written backwards (on a map from right to left).
'god' back-to-front is 'DOG'.
(Other definitions for dog that I've seen before include "'Every . . . has its day'" , "Worry" , "Shadow" , "Cur" , "Domestic animal" .)