Following a twist of fate, remorse begins (5)
I believe the answer is:
after
'following' is the definition.
(I've seen this in another clue)
'a twist of fate remorse begins' is the wordplay.
'a twist of' is an anagram indicator (I've seen 'twisted' mean this).
'begins' suggests taking the first letters.
The first letter of 'remorse' is 'r'.
'fate' with letters rearranged gives 'afte'.
'afte'+'r'='AFTER'
(Other definitions for after that I've seen before include "Behind; seeking" , "In pursuit of, behind" , "Looking for" , "In honour of" , "In the time following" .)