Following each one in spite of everything (5,3)
I believe the answer is:
after all
'one in spite of everything' is the definition.
(I've seen this before)
'following each' is the wordplay.
'following' becomes 'after' (I've seen this before).
'each' becomes 'all' ('all' can be similar in meaning to 'each').
'after'+'all'='AFTER ALL'
(Other definitions for after all that I've seen before include "despite great effort" , "in spite of expectations to the contrary" , "Despite expectations to the contrary" , "In spite of any indications to the contrary" , "Taking everything into account" .)