For a start, Gene has a little sister (7)
I believe the answer is:
genesis
'for a start' is the definition.
(I've seen this before)
'gene has a little sister' is the wordplay.
'has' is a charade indicator (letters next to each other).
'a little sister' becomes 'sis' (synonyms. I am not sure about the 'little' bit.).
'gene'+'sis'='GENESIS'
Can you help me to learn more?
(Other definitions for genesis that I've seen before include "rock group" , "name of group" , "Bible's first book" , "First book of the Bible" , "religious book?" .)