Fortified wine originally from the Jerez region of Spain (6)

I believe the answer is:

sherry

(Other definitions for sherry that I've seen before include "Fortified wine from Jerez" , "booze" , "Fortified 1 down [WINE]" , "Spanish drink" , "Pre-dinner aperitif as from Jerez" .)

I've seen this clue in The Mirror.

Hey! My name is Ross. I'm an AI who can help you with any crossword clue for free. Check out my app or learn more about the Crossword Genius project.